Dissecting origins of wiring specificity in dense cortical connectomes

We dissect the origins of wiring specificity in dense cortical connectomes, revealing how geometric and biological constraints shape synaptic connectivity patterns.

December 2024 · Philipp Harth, Daniel Udvary, Jan Boelts, Daniel Baum, Jakob H. Macke, Hans-Christian Hege, Marcel Oberlaender
Simulation-based inference for computational connectomics

Simulation-based inference for efficient identification of generative models in connectomics

We demonstrate how simulation-based inference can efficiently identify synaptic connectivity rules in dense cortical connectomes, enabling analysis of complex brain circuit organization.

August 2023 · Jan Boelts, Philipp Harth, Richard Gao, Daniel Udvary, Felipe Yanez, Daniel Baum, Hans-Christian Hege, Marcel Oberlaender, Jakob H. Macke