Dissecting origins of wiring specificity in dense cortical connectomes

We dissect the origins of wiring specificity in dense cortical connectomes, revealing how geometric and biological constraints shape synaptic connectivity patterns.

December 2024 · Philipp Harth, Daniel Udvary, Jan Boelts, Daniel Baum, Jakob H. Macke, Hans-Christian Hege, Marcel Oberlaender
Simulation-based inference for computational connectomics

Simulation-based inference for efficient identification of generative models in connectomics

We demonstrate how simulation-based inference can efficiently identify synaptic connectivity rules in dense cortical connectomes, enabling analysis of complex brain circuit organization.

August 2023 · Jan Boelts, Philipp Harth, Richard Gao, Daniel Udvary, Felipe Yanez, Daniel Baum, Hans-Christian Hege, Marcel Oberlaender, Jakob H. Macke

Simulation-Based Inference for Computational Neuroscience

Invited presentation at the Bernstein Center for Computational Neuroscience Berlin on using SBI methods for parameter inference in models of neural circuits and behavior.

November 2022 · Jan Boelts
Mixed Neural Likelihood Estimation

Flexible and efficient simulation-based inference for models of decision-making

We propose a new method to perform simulation-based inference for mixed data e.g., with continuous and discrete data types, like they often occur in models of decision-making.

July 2022 · Jan Boelts, Jan-Matthis Lueckmann, Richard Gao, Jakob H. Macke